Pay-for-success contracts or retroactive public goods funding can solve the tragedy of commons for development of unmonopolisable therapies e.g. finding new uses for off-patent drugs, plant medicines, supplements, diets and lifestyle intervetions. If governments, health insuers, philanthropy and public agree to back a Prize Fund via issue of Public Good Medical Prize NFTs, this can lead to trillions of dollars in healthcare cost savings because it can be 100 times less costly and 10 times faster than patent-centric drug development, by relying on existing Phase 1 safety data.